Integrative View of Cancer, Diet, and Gut Bacteria

If you have understood the profound implications of the fact that 2/3 of our Immune/Detoxification system is made up of gut flora then these articles will not surprise you:

The Intestinal Microbiome and Estrogen Receptor–Positive Female Breast Cancer
JNCI J Natl Cancer Inst (2016) djw029 doi:10.1093/jnci/djw029 First published online April 22, 2016

“The huge communities of residential microbes, including bacteria, viruses, Archaea, and Eukaryotes, that colonize humans are increasingly recognized as playing important roles in health and disease. A complex populous ecosystem, the human gastrointestinal (GI) tract harbors up to 1011 bacterial cells per gram of luminal content, whose collective genome, the gut metagenome, contains a vastly greater number of individual genes than the human genome. In health, the function of the microbiome might be considered to be in dynamic equilibrium with the host, exerting both local and distant effects. However, ‘disequilibrium’ may contribute to the emergence of disease, including malignancy. In this review, we discuss how the intestinal bacterial microbiome and in particular how an ‘estrobolome,’ the aggregate of enteric bacterial genes capable of metabolizing estrogens, might affect women’s risk of developing postmenopausal estrogen receptor–positive breast cancer. Estrobolome composition is impacted by factors that modulate its functional activity. Exploring variations in the composition and activities of the estrobolome in healthy individuals and in women with estrogen-driven breast cancer may lead to development of microbiome-based biomarkers and future targeted interventions to attenuate cancer risk.”

Eating three servings of fruit in adolescence may reduce risk of breast cancer, study suggests

TIME (5/11, Park) reports new research published in the British Medical Journal analyzed how diet during adolescence may affect cancer risk. Researchers found that nearly half of the 90,000 women who participated in a Nurses’ Health Study answered questions regarding their diets while they were teens. From this information, the researchers found that “those who reported eating nearly three servings of fruit a day on average had a 25% lower risk of developing breast cancer than those who ate half a serving of fruit.”

Conversely, HealthDay (5/11, Mozes) reports that “women who drink more alcohol over time might increase their breast cancer risk.” According to the article, “food and drink consumption was also tallied once every four years from 1991 to 2013, at which point the women were asked to recall their diets over the prior year.” Over the two decades of the study, more than “3,200 women developed invasive breast cancer.” HealthDay notes that “adolescent dietary information was available for about 1,350 of those women.”

This is one of hundreds of articles proving that our diets and a toxic environment are the reason we develop cancer. Those who continue to blame our genes ignore the implications of the emerging field of EPIGENOMICS. EPI means “above.” What is above genetics?

“Combating Environmental Causes of Cancer,” NEJM 2011;364:7991

“Nutrients and Epigenetic Regulation of Gene Expression” J. Nutr. 2009 139: 2387

 

LANDMARK ARTICLE WORTH HIGHLIGHT AGAIN

“Apoptosis by dietary factors,” J. Carcinogenesis 2007;28:233

  • “In spite of substantial progress in the development of anticancer therapies, the incidence of cancer is still increasing worldwide. Recently, chemoprevention by the use of naturally occurring dietary substances is considered as a practical approach to reduce the ever-increasing incidence of cancer.”
  • “By making modifications in the diet, more than 2/3 of human cancers could be prevented…. Dietary chemopreventive compounds offer great potential in the fight against cancer by inhibiting the carcinogenesis process through the regulation of cell defensive and cell death machineries.”
  • “Apoptosis, a form of programmed cell death, plays a fundamental role in the maintenance of tissues and organ systems by providing a controlled cell deletion to balanced cell proliferation. The last decade has witnessed an exponential increase in the number of studies investigating how different components of the diet interact at the molecular and cellular level to determine the fate of a cell. It is now apparent that many dietary chemopreventive agents with promise for human consumption can also preferentially inhibit the growth of tumor cells by targeting one or more signaling intermediates leading to induction of apoptosis.”
  • “The two major pathways that initiate apoptosis are extrinsic (death receptor-mediated,) and intrinsic (mitochondrial mediated.) Mitogenic and stress responsive pathways are involved in the regulation of apoptotic signaling. Noteworthy is the crosstalk between some of these pathways.”
Hugo Rodier, MD is an integrative physician based in Draper, Utah who specializes in healing chronic disease at the cellular level by blending proper nutrition, lifestyle changes, & allopathic practices when necessary.

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